You are here: Startpage > Pharma Research > Local Tolerability

Local tolerability of topical medicinal products

Topical medications must be tested according to international guidelines for local tolerability. With a service portfolio consisting of internationally recognized protocols that cover the requirements of European and U.S. licensing authorities, proDERM Pharma is available to you as an experienced and competent partner.

Often, when determining the local tolerability of a product, irritative and allergenic potentials must be excluded. If the formulation contains active substances or excipients that absorb within the UV spectrum, the photoallergenic potential must also be excluded. But for rarer issues as well, such as tolerability on mucous membranes or wounds, we have standard protocols and extensive experience at our disposal.

News and Events

Non-Invasive Measurement of Age-Related Skin Damage

Presentation by Stephan Bielfeldt at the Anti-Ageing Skin Care Conference


Decision of British Advertising Standards Authority (ASA) confirms:

proDERM Quality Seal provides solid substantiation of "dermatologically approved" claims


  • 21 Days Irritation Patch Test
  • Repeated Open Application Test (ROAT)
  • In-vivo Phototoxicity
  • In-vivo Photosensitivity
  • Human Repeat Insult Patch Test (HRIPT)
  • Scratch Patch/Chamber Test
  • Local Eye Tolerability
  • Blanching
  • Acne
  • Atopic Dermatitis
  • Psoriasis
  • Type I & IV Allergy
  • Rosacea
  • Dry Eyes
  • Inflammation / wound healing
  • Hyperhidrosis
  • Herpes simplex
  • Tewameter
  • IR Thermography
  • Chromametry
  • UVA/UBA Irradiation
  • Corneometry
  • Confocal Microscopy
  • Laser Doppler
  • Ultrasound
  • FLPI
  • USR-CliP: Unit for standardized and
    reproducible clinical photography
  • Raman Spectroscopy

...the FDA demands for the assesment of the "Local Tolerability" of new chemical entities and generics the following four studies:

  • 21 Days Irritation Patch Test
  • HRIPT
  • Phototoxicity
  • Photosensitivity