Clinical Photography

Clinical photography is a recognized parameter in clinical studies. The photography systems used must meet the highest demands of standardization and reproducibility. Lighting, color fidelity, positioning – all the settings themselves must be reproducible over a period of several months. In addition, a system should be mobile, applicable in many situations and secure, and it should also produce images of superior quality. Commercially available systems usually do not provide the combination of all these properties. Since the requirement for high-quality clinical photography is continually increasing, we have developed our own units.

These include a fully automated photography laboratory (USR-CliP – Unit for Standardized and Reproducible Clinical Photography), a system for macro photography, a unit for test areas >50 cm2, a face photography stand, etc. Clinical photos can be used for documentation purposes and may be crucial parameters in clinical trials. The fields of application are manifold – thus, study proofs, for instance for skin diseases such as psoriasis, rosacea and acne, can be conducted. The same applies to the reduction of herpes or pigmentation. Anti-aging proofs, efficacy studies in the areas of attractiveness and decorative cosmetics, to the examination of specific claims such as “brighter teeth” or “fewer scales”.

Possible fields of application of our systems

  • Anti-Age
  • Anti-Acne
  • Anti-Herpes
  • Anti-Psoriasis
  • Anti-Rosacea
  • Attractiveness
  • Decorative cosmetics
  • Depigmentation
  • Tooth color
  • Wounds

proDERM | Your partner for trustworthy clinical studies.

In Dermatology, Oral Care, Ophthalmology, Hair Care, Women’s Health and Sun Care

Skin profilometry

Using profilometry, the surface structure of human skin can be imaged three-dimensionally. The basis of the method is the digital projection of stripes onto the skin. This image on the measurement object is then recorded with a camera. The height image of the measurement object is then calculated from the position of the stripes and the gray value of the individual pixels. Depending on your needs, we can use two different profilometric methods in your clinical studies. We recommend the DermaTOP for the targeted examination of roughness parameters, for instance in the field of anti-wrinkle efficacy. A more global examination of the face is possible with the AEVA-He multi-parametric measurement method in which wrinkles and lines (periorbital, nasolabial and other areas), pores, tear sacs and facial contours (sagging) are examined.

Possible Parameters:

  • Skin roughness
  • Lines and wrinkles
  • Elasticity / Sagging
  • Eye bags
  • Pores and more

Imaging procedures

Using imaging techniques, we can determine various relevant parameters in vivo. For example, we can use confocal microscopy to non-invasively record single layers of skin up to a depth of 350 μm and thereby visualize optical sections with a layer thickness of less than 5 μm. The ultrasound method allows the determination of skin thickness, whereby skin structures are reproduced with a resolution of 0.072 mm up to a maximum depth of 8 mm. Thermography is an imaging method of temperature measurement using an infrared camera, and with the “Full Field Laser Perfusion Imager” we measure the blood perfusion of the upper skin layers without touching the skin.

Possible parameters:

  • Epidermal thickness
  • Papillary density and structure
  • Skin thickness
  • Temperature
  • Skin blood circulation
  • Moisture Mapping

In vivo molecular analysis

The determination of relevant parameters at the molecular level is carried out on the basis of the Raman spectrometer. The Raman spectrometer combines the possibilities of spectrometric quantification of molecules with confocal microscopy. This enables us to measure important molecular parameters quickly, precisely and non-invasively, exactly where it matters – in different skin layers directly on the test subject. With this procedure, we determine the following parameters:

  • Penetration of actives
  • Natural Moistuirizing Factor (NMF) – Content as well as quantification of specific NMF-components
  • Quantification of horny layer lipids
  • Stratum corneum thickness determination
  • Water content in the Stratum corneum

Classic in vivo measurement procedures

We are experts in clinical studies in the areas of skin, mucosa, hair, eyes and oral cavity. In addition to the above procedures, we provide classic measurement methods for all these areas for the investigation of established parameters. From determining skin hydration to measuring intraocular pressure to exploring the sensitivity of teeth – when planning your study design and conducting your study, we can tailor it to your needs thanks to our extensive portfolio of methods and equipment.

Selection of additional parameters

  • Skin color
  • Skin moisturization
  • Skin elasticity
  • Transepidermal water loss
  • Transepidermaler Wasserverlust
  • Secretion of skin sebum
  • pH-Value
  • Teeth sensitivity
  • Interior eye pressure and more