Effective wound healing
In addition to the purely physical effect of providing coverage for a wound, a patch can also help with healing properties. The effectiveness of a patch in terms of wound healing can be studied using a variety of methods. For dry wound healing concepts, techniques such as the abrasive wound method or the suction blister method are suitable. Wet wound healing concepts, on the other hand, are tested using the maceration method. A CE label for the test product is mandatory for the performance of wound healing studies.
The abrasive wound method
The abrasive wound method enables studies of a test product’s wound healing properties, for example in comparison to a reference product. First, a sterile brush is used to create a wound. This is then followed by an application phase with the test product, usually lasting 14 days, in which the healing of the wound is documented using digital photographs and visual scoring. The study is analyzed based on a “wound size” parameter using special analysis software.
The suction blister method
The suction blister method is an alternative method for determining the wound healing properties of a test product. The wound is created using a vacuum unit, which generates a suction blister in a test area, and the skin on the blister is removed. This creates a highly standardised wound that heals without leaving a scar.
Maceration techniques are used to determine the effectiveness of wet wound healing methods. This model involves the test product being applied to the wound for a longer period of time. A comparison with an untreated wound then allows for conclusions about the effectiveness of the patch intended to support wound healing. Alternatively, a comparison with a dry product or other reference product is also possible.