Testing and examining the efficacy of anti-aging products

Efficacy studies related to skin aging parameters such as wrinkles and lines, age spots, volume loss, atrophy and more.

Efficacy of anti-aging products

Both intrinsic and extrinsic factors are responsible for the aging of the skin. The changes associated with the aging process of the skin are varied: The epidermis becomes thin and the collagen content of the dermis decreases as well as the fat content and elasticity. The subcutaneous tissue loses volume. On the surface, old skin appears wrinkled, irregularly pigmented, dry and limp. Dark circles around the eyes, swollen lower eyelids and other features are also known indicators of the skin aging process. The determination of the efficacy of an anti-aging product can therefore be based on a number of different parameters. The study design should be focused precisely on the mode of action of your product and take into account the appropriate target parameters.

We don’t want to set limits to your drive for research! From the classic anti-wrinkle efficacy study, to the demonstration of the most innovative parameters, such as water mobility or papilla index to the global, multi-parametric investigation of skin aging in the face – we are happy to assist you with a variety of approaches in efficacy testing. For proof of the efficacy of your product, we can consider the following parameters to study the characteristics of aging skin:


  • AGEs (Advanced Glycation Endproducts)
  • Antioxidant Status
  • Image evaluation
  • Epidermal thickness
  • Skin Whitening
  • Skin moisturization
  • Skin blood circulation
  • Skin elasticity
  • Skin color
  • Skin firmness
  • Skin dryness
  • Skin volume
  • Lifting
  • Natural Moisturizing Factor
  • Papillary index
  • Quantitative image analysis
  • Topographical parameters Rz, Ra
  • Transepidermal water loss

Signs of aging skin

  • Age spots / pigmentation
  • Atrophy
  • Increased skin roughness
  • Increased skin dryness
  • Lines and wrinkles
  • Reduced skin elasticity
  • Limp facial contours
  • Éclat du Teint
  • Uneven skin
  • Increased size of pores
  • Increased lacrimal sac
  • Loss of volume
  • Occurrence of eye bags

Our classic: anti-wrinkle efficacy after multiple applications

Our “anti-wrinkle efficacy” study design examines the wrinkle-smoothing effect of a test product after four weeks of use. We determine the skin folds and moisture; at the end of the study, the test subjects answer questions on product properties and cosmetic acceptance. The measurement of the skin folds takes place in the area of the so-called crow’s feet, while the determination of skin moisture in the half-side test is carried out on the cheekbones. Test subjects are recruited according to the proDERM fold score, and the study is performed in fully air-conditioned examination rooms after 30 minutes of acclimatization.

We offer this classic study design in two variants: On the one hand, it has been expanded to include the determination of skin elasticity and accompanying photo documentation using proDERM USR-CliP, and on the other hand, an integrated interim evaluation. We are also happy to create an individual study design for you on request.

proDERM | Your partner for trustworthy clinical studies.

In Dermatology, Oral Care, Ophthalmology, Hair Care, Women’s Health and Sun Care

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Clinical Testing of Anti-Age Products

How to demonstrate the efficacy of products claiming to provide anti-age effects?

You can request our FactSheet on “Clinical Testing of Anti Age Products” using our contact form.

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