Bad breath, tooth color, plaque and more – carrying out proof of effectiveness and claim support studies for oral care products.
Products that are applied in the oral cavity can be evaluated using different criteria, such as bad breath, tooth color, plaque, gingivitis and sensitivity. In each case, proDERM Cosmetics has an appropriate method to demonstrate efficacy. Validated methods such as OralChroma, Odor Judges trained by proDERM and unique image assessment methods such as the proDERM USR-CliP (Unit for Standardized and Reproducible Clinical Photography) are used. Our dentists were trained at reference centres specifically for studies evaluating numerous parameter. For our studies, approximately 1,000 subjects who have been “prescreened” with regard to their dental status are available. This enables fast and effective recruitment, even for studies with a high number of test subjects.
In Dermatology, Oral Care, Ophthalmology, Hair Care, Women’s Health and Sun Care
The gold standard for determining the efficacy of products which are supposed to reduce halitosis is the organoleptic test. We have a group of eight trained odor judges check the breath of the test subjects. In order to exclude any influence of the external appearance of the test persons on the odor judges, the test takes place at a defined distance behind a partition wall.
In addition to this organoleptic procedure, we use the objective technical method of gas chromatography, with which sulfur compounds can be determined. These sulfur compounds are released by anaerobic bacteria and are primarily responsible for halitosis. Very low concentrations in the lower millionth range can be detected. The molecules responsible for halitosis – hydrogen sulfide, dimethyl sulfide and methylmercaptan – are measured.
The efficacy of formulations for fighting plaque in the interdental space and gingivitis is investigated by examining the gingiva of the test subjects prior to the start of the study and after the period of application. In addition, the plaque index and gingivitis index may be evaluated by a dentist to determine the efficacy of treatment with an oral care product.
Tooth shade can also be the object of an investigation. The Vita Shade System can be used to check whether some products lead to unwanted discoloration (such as mouth rinses) and whether others cause a straightforward whitening of the teeth (e.g., chewing gum).
You can request our FactSheet on “Oral Care” using our contact form.